Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-OH

Base Information

Chemical Name:Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-OH
CAS No.:1048703-66-7
Molecular Formula:C₁₁₇H₁₆₄N₁₈O₂₅S₂
Molecular Weight:2286.83
Hs Code.:

Synonyms:Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-OH

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Chemical Property of Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-OH

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Technology Process of Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-OH

There total 1 articles about Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 68858-20-8
Fmoc-Val-OH

: 35661-60-0
Fmoc-Leu-OH

: 35661-40-6
N-Fmoc L-Phe

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 71989-23-6,251316-98-0
Fmoc-Ile-OH

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 143824-78-6,163619-04-3
3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester

: 187618-60-6
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 1048703-66-7
Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-OH

Guidance literature:: N-(fluoren-9-ylmethoxycarbonyl)glycine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Automated synthesizer; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; Automated synthesizer; solid phase reaction;

Fmoc-Val-OH; Fmoc-Leu-OH; N-Fmoc L-Phe; Fmoc-Glu(OtBu)-OH; Fmoc-Ile-OH; Fmoc-Lys(tert-butoxycarbonyl); 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;
DOI:10.1002/ejoc.200800722

Reference yield: 97.0%

: H-Arg(Pbf)-Cys(Trt)-OtBu

: 1048703-66-7
Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-OH

: Fmoc-Arg(Pbf)-Glu(OtBu)-Phe-Ile-Lys(Boc)-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Cys(Trt)-OtBu

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1002/ejoc.200800722