17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.0^4,9]hexacosane-2,3,10,16-tetraone

Base Information

• Chemical Name: 17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.0^4,9]hexacosane-2,3,10,16-tetraone
• CAS No.: 261759-01-7
• Molecular Formula: C₄₃H₆₉NO₁₂
• Molecular Weight: 792.02
• Mol file: 261759-01-7.mol

Synonyms:17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.0^4,9]hexacosane-2,3,10,16-tetraone

Chemical Property of 17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.0^4,9]hexacosane-2,3,10,16-tetraone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.0^4,9]hexacosane-2,3,10,16-tetraone

There total 3 articles about 17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.0^4,9]hexacosane-2,3,10,16-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

ascomycin (135635-46-0,137767-76-1,104987-12-4,133876-12-7) → 1-formyl-piperidine-2-carboxylic acid 6-ethyl-3-hydroxy-1-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-12-methoxy-12-(3-methoxy-5-methyl-6-oxo-tetrahydro-pyran-2-yl)-2,8,10-trimethyl-5-oxo-dodec-7-enyl ester + C43H69NO12 + 17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.04,9]hexacosane-2,3,10,16-tetraone (261759-01-7)

Guidance literature:

In acetonitrile; at 25 ℃; for 2h; Product distribution; Photolysis;

Reference yield: 22.0%

methanol (67-56-1) + ascomycin (135635-46-0,137767-76-1,104987-12-4,133876-12-7) → 1-formyl-piperidine-2-carboxylic acid 6-ethyl-3-hydroxy-1-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-12-methoxy-12-(3-methoxy-5-methyl-6-oxo-tetrahydro-pyran-2-yl)-2,8,10-trimethyl-5-oxo-dodec-7-enyl ester + 17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.04,9]hexacosane-2,3,10,16-tetraone (261759-01-7) + 4-β-methoxy-9-dihydroascomycin (261759-00-6) + 17-but-1-enyl-1,2,14-trihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-5,21,23-trimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.04,9]hexacosane-3,10,16-trione

Guidance literature:

at 25 ℃; for 2h; Further Variations:; wavelength; Product distribution; Photolysis;

Reference yield: 10.0%

ascomycin (135635-46-0,137767-76-1,104987-12-4,133876-12-7) → C43H69NO12 (1173295-59-4) + C43H69NO12 (1173295-60-7) + 1-formyl-piperidine-2-carboxylic acid 6-ethyl-3-hydroxy-1-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-12-methoxy-12-(3-methoxy-5-methyl-6-oxo-tetrahydro-pyran-2-yl)-2,8,10-trimethyl-5-oxo-dodec-7-enyl ester + 17-but-1-enyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-21,23-dimethoxy-13,17,19,25-tetramethyl-11,26-dioxa-4-aza-tricyclo[20.3.1.04,9]hexacosane-2,3,10,16-tetraone (261759-01-7)

Guidance literature:

With water; In acetonitrile; at 20 ℃; for 2h; Irradiation >280 nm;

DOI:10.1002/hlca.200800436

upstream raw materials:

methanol

ascomycin