(S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Base Information

Chemical Name:(S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate
CAS No.:1609191-14-1
Molecular Formula:C₃₀H₃₄N₄O₄
Molecular Weight:514.624
Hs Code.:

Synonyms:(S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

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Chemical Property of (S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

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Technology Process of (S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

There total 8 articles about (S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-(1-(((benzyloxy)carbonyl)amino)-6-carboxyhexyl)-5-(6-methoxynaphthalen-2-yl)-1H-imidazol-3-ium trifluoroacetate

: 74-89-5
methylamine

: 1609191-14-1
(S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: (S)-2-(1-(((benzyloxy)carbonyl)amino)-6-carboxyhexyl)-5-(6-methoxynaphthalen-2-yl)-1H-imidazol-3-ium trifluoroacetate; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.166667h;

methylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1609191-02-7
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-(methoxy(methyl)amino)-8-oxooctanoate

: 1609191-14-1
(S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C

2.1: ammonia / methanol / 72 h / 20 °C / Sealed tube

3.1: N-iodo-succinimide / acetonitrile / 2 h / -10 °C

4.1: sodium sulfite; tetrabutylammonium dihydrogen phosphate / water; 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

5.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate / water; 1,2-dimethoxyethane / 0.67 h / 110 °C

6.1: dichloromethane / 2 h / 0 - 20 °C

7.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

7.2: 16 h / 20 °C

With N-iodo-succinimide; lithium aluminium tetrahydride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; ammonia; potassium carbonate; tetrabutylammonium dihydrogen phosphate; N-ethyl-N,N-diisopropylamine; HATU; sodium sulfite; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 49645-27-4
(S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid

: 1609191-14-1
(S)-benzyl (1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 16 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C

3.1: ammonia / methanol / 72 h / 20 °C / Sealed tube

4.1: N-iodo-succinimide / acetonitrile / 2 h / -10 °C

5.1: sodium sulfite; tetrabutylammonium dihydrogen phosphate / water; 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

6.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate / water; 1,2-dimethoxyethane / 0.67 h / 110 °C

7.1: dichloromethane / 2 h / 0 - 20 °C

8.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

8.2: 16 h / 20 °C

With N-iodo-succinimide; lithium aluminium tetrahydride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; ammonia; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; tetrabutylammonium dihydrogen phosphate; N-ethyl-N,N-diisopropylamine; HATU; sodium sulfite; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;