(αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

Base Information

Chemical Name:(αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate
CAS No.:226387-97-9
Molecular Formula:C₂₃H₂₂N₂O₅
Molecular Weight:406.438
Hs Code.:

Synonyms:(αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

Suppliers and Price of (αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

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Technology Process of (αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

There total 3 articles about (αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 169221-13-0
(R)-3-hydroxy-4,4-dimethyl-1-phenylpyrrolidin-2-one

: 53701-47-6
2-(1,3-dioxoisoindolin-2-yl)propanoyl chloride

: 226387-97-9,496785-30-9
(αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

: 496785-30-9
(αR,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

Guidance literature:: With 4 A molecular sieve; triethylamine; In tetrahydrofuran; for 2.5h; Yields of byproduct given; Ambient temperature;
DOI:10.1016/S0957-4166(99)00018-X

Reference yield:

: 21860-84-4
2-phthalimidopropionic acid

: 226387-97-9,496785-30-9
(αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 15 h / Heating

2: 76 percent / Et₃N, 4A molecular sieves / tetrahydrofuran / 2.5 h / Ambient temperature

With thionyl chloride; 4 A molecular sieve; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0957-4166(99)00018-X

Reference yield:

: 169221-13-0
(R)-3-hydroxy-4,4-dimethyl-1-phenylpyrrolidin-2-one

: 21860-84-4
2-phthalimidopropionic acid

: 226387-97-9,496785-30-9
(αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

: 496785-30-9
(αR,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-phthalimidopropanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 96h; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1016/S0957-4166(99)00018-X