53701-47-6Relevant articles and documents
New fluorescent and colorimetric chemosensors based on the rhodamine detection of Hg2+ and Al3+ and application of imaging in living cells
Yan, Fanyong,Wang, Meng,Cao, Donglei,Yang, Ning,Fu, Yang,Chen, Li,Chen, Ligong
, p. 42 - 50 (2013)
Employing the "OffeOn" switching of the spirocyclic moiety in Rhodamine B derivatives, three sensors were designed and characterized as new fluorescent probes for detecting Hg2+ and Al3+ in the environment, respectively. The first probe exhibited chromogenic and fluorogenic selectivity to detection of Hg2+ in methanol-H2O (4:6, v/v, HEPES, pH 7.0). The first and second probes displayed fluorescence intensity enhancement following Hg2+ coordination with limits of detection for Hg2+ at the ppb level. The limit of detection based on 3 blank/k was calculated to be 2.5 × 10-8 M and 4.2 × 10-8 M, respectively. The third probe contained a benzyl group which resulted in better selectivity for Al3+. Job's plot clearly suggested the formation of 1:1 complexation behavior between the three probes and Hg 2+ or Al3+. The three probes can be used as a fluorescent probe for monitoring Hg2+ or Al3+ in living cells with satisfying results, which demonstrates the value of the probes in practical applications in environmental and biological systems.
A Novel Class of 7-Membered Heterocyclic Compounds
Bauer, Adriano,Borsos, Eszter,Maulide, Nuno
, p. 3971 - 3974 (2020/05/25)
The work presented herein describes the synthesis of a formerly inaccessible class of heterocyclic compounds. The reaction relies on α-phthalimido-amides, which are readily prepared from amino acids in 2 simple reactions steps. Under amide activation conditions in which classical keteniminium ions are not formed, the nitrile solvent is incorporated into the new fused 7-membered ring system. Due to the absence of a keteniminium intermediate, the stereogenic information in the α-position is fully retained.
Synthesis of Quaternary α-Fluorinated α-Amino Acid Derivatives via Coordinating Cu(II) Catalytic α-C(sp3)-H Direct Fluorination
Wei, Qiang,Ma, Yao,Li, Li,Liu, Qingfei,Liu, Zijie,Liu, Gang
, p. 7100 - 7103 (2018/11/24)
A coordinating, copper-catalyzed direct α-C(sp3)-H fluorination method has been developed to prepare vital quaternary α-fluorinated α-amino acid derivatives. A Cu(II) catalytic SET oxidative addition mechanism is proposed, involving a key fluoride-coupled Cu(II) charge transfer complex. The protocol can tolerate a rich variety of α-amino acids, for which the auxiliary group is removed in high yield and substituted for the direct preparation of dipeptide derivatives with detachable, single absolute configurations of the target compounds.
