((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone

Base Information

Chemical Name:((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone
CAS No.:132557-15-4
Molecular Formula:C₂₄H₂₉BrN₂O
Molecular Weight:441.411
Hs Code.:

Synonyms:((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone

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Chemical Property of ((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone

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Technology Process of ((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone

There total 14 articles about ((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 132557-14-3
((2aR,4S)-4-Amino-6-bromo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone

: 107-08-4
1-iodo-propane

: 132557-15-4
((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃;
DOI:10.1016/S0040-4039(00)97303-9

Reference yield:

: 132557-13-2,132619-32-0,141434-26-6
Phenyl-[(5aR,6aS,7aR)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone

: 132557-15-4
((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / H₂, phosphoric acid, KOH / Pd/C / H₂O; tetrahydrofuran / 6 h / 0 - 55 °C / 760 Torr

2: 88.8 percent / Br₂, NaOAc / acetic acid / Ambient temperature

3: 80 percent / K₂CO₃ / acetonitrile / 75 °C

With potassium hydroxide; phosphoric acid; hydrogen; bromine; sodium acetate; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; water; acetic acid; acetonitrile;
DOI:10.1021/jo971256z

Reference yield:

: 132557-12-1
[(2aR,4R,5R)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone

: 132557-15-4
((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 84.5 percent / PPh₃, DEAD / tetrahydrofuran / Ambient temperature

2: 71 percent / H₂, phosphoric acid, KOH / Pd/C / H₂O; tetrahydrofuran / 6 h / 0 - 55 °C / 760 Torr

3: 88.8 percent / Br₂, NaOAc / acetic acid / Ambient temperature

4: 80 percent / K₂CO₃ / acetonitrile / 75 °C

With potassium hydroxide; phosphoric acid; hydrogen; bromine; sodium acetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; water; acetic acid; acetonitrile;
DOI:10.1021/jo971256z