6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile

Base Information

• Chemical Name: 6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile
• CAS No.: 107199-96-2
• Molecular Formula: C₁₂H₁₁N₅
• Molecular Weight: 225.253

Synonyms:6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile

Chemical Property of 6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile

Chemical Property:

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Technology Process of 6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile

There total 5 articles about 6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 4-methyl-benzaldehyde (104-87-0) + malononitrile (109-77-3) → 6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile (107199-96-2)

Guidance literature:

With ZnO nanoparticles; In water; at 20 ℃; for 0.25h;

DOI:10.1080/00397910903219385

Reference yield: 94.0%

guanidine nitrate (506-93-4) + 4-methyl-benzaldehyde (104-87-0) + malononitrile (109-77-3) → 6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile (107199-96-2)

Guidance literature:

With nickel(II) chromite; In ethanol; at 20 ℃; for 0.25h; Sonication; Green chemistry;

DOI:10.2174/1386207323666200808180527

Reference yield: 91.0%

guanidine hydrochloride (50-01-1) + 4-methyl-benzaldehyde (104-87-0) + malononitrile (109-77-3) → 6-oxo-2-phenyl-4-[4-(trifluoromethyl)phenyl]-1,6-dihydro-5-pyrimidinecarbonitrile (107199-96-2)

Guidance literature:

at 60 ℃; for 0.05h; Microwave irradiation; Ionic liquid;

DOI:10.1002/jhet.540

upstream raw materials:

2-amino-6-phenyl-4-p-tolyl-4H-pyran-3,5-dicarbonitrile

guanidine hydrochloride

ethyl 6-amino-5-cyano-2-phenyl-4-(p-tolyl)-4H-pyran-3-carboxylate

4-methyl-benzaldehyde

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