6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol

Base Information

• Chemical Name: 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol
• CAS No.: 1263383-04-5
• Molecular Formula: C₄₉H₈₆N₄O₁₉
• Molecular Weight: 1035.24

Synonyms:6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol

Chemical Property of 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol

Chemical Property:

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Technology Process of 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol

There total 7 articles about 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C21H25F5N2O6 (1060775-31-6) + 6-amino-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol hydrochloride → 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol (1263383-04-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 - 25 ℃;

DOI:10.1007/s11426-010-4136-3

Reference yield:

(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)formic acid → 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol (1263383-04-5)

Guidance literature:

Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide / dichloromethane / 12 h / -15 - 25 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / -15 - 25 °C

3: hydrogenchloride / tetrahydrofuran; water / 10 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / -15 - 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1007/s11426-010-4136-3

Reference yield:

6-(tert-butoxycarbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol (1263383-01-2) → 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol (1263383-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran; water / 10 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / -15 - 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1007/s11426-010-4136-3

upstream raw materials:

methyl 3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)-ethoxy)benzoate

6-(tert-butoxycarbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol

C₂₁H₂₅F₅N₂O₆

N^α-(benzyloxycarbonyl)-N^ε-(tert-butoxycarbonyl)-L-lysine methyl ester

Downstream raw materials:

6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl methacrylate

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