(4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate

Base Information

• Chemical Name: (4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate
• CAS No.: 1375692-97-9
• Molecular Formula: C₄₈H₅₇F₃O₆
• Molecular Weight: 786.972
• Mol file: 1375692-97-9.mol

Synonyms:(4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate

Chemical Property of (4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate

There total 3 articles about (4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

acide chromone carboxylique-2 (4940-39-0) + (4-(trifluoromethyl)benzyl) 3β-hydroxy-olean-12-en-30-oate (1375692-79-7) → (4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate (1375692-97-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Reflux;

DOI:10.1016/j.bmcl.2012.03.081

Reference yield:

11-deoxyglycyrrhetinic acid (6894-46-8,14796-53-3,17956-00-2,76035-62-6,564-16-9) → (4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate (1375692-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Reflux

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.081

Reference yield:

enoxolone (471-53-4) → (4-(trifluoromethyl)benzyl) 3-O-(4-oxo-4H-1-benzopyran-2-carbonyl)-olean-12-en-30-oate (1375692-97-9)

Guidance literature:

Multi-step reaction with 3 steps

1: platinum(IV) oxide; hydrogen / acetic acid

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Reflux

With dmap; platinum(IV) oxide; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.081

upstream raw materials:

acide chromone carboxylique-2

(4-(trifluoromethyl)benzyl) 3β-hydroxy-olean-12-en-30-oate

enoxolone

11-deoxyglycyrrhetinic acid