N₁-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N₂-[(4-nitrophenyl)sulfonyl]glycinamide

Base Information

• Chemical Name: N₁-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N₂-[(4-nitrophenyl)sulfonyl]glycinamide
• CAS No.: 1297141-72-0
• Molecular Formula: C₁₈H₂₉N₃O₆SSi
• Molecular Weight: 443.596

Synonyms:N₁-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N₂-[(4-nitrophenyl)sulfonyl]glycinamide

Chemical Property of N₁-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N₂-[(4-nitrophenyl)sulfonyl]glycinamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N₁-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N₂-[(4-nitrophenyl)sulfonyl]glycinamide

There total 3 articles about N₁-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N₂-[(4-nitrophenyl)sulfonyl]glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(S)-1-((tert-butyldimethylsilyl)oxy)but-3-en-2-amine (1297141-69-5) + 2-[(4-nitrobenzene)sulfonamido]acetic acid (15054-44-1) → N1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N2-[(4-nitrophenyl)sulfonyl]glycinamide (1297141-72-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → N1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N2-[(4-nitrophenyl)sulfonyl]glycinamide (1297141-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / 2.5 h / 0 °C / pH > 9

1.2: pH 1

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → N1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N2-[(4-nitrophenyl)sulfonyl]glycinamide (1297141-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

With 2,6-dimethylpyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-Nitrobenzenesulfonyl chloride

t-butyldimethylsiyl triflate

(S)-1-((tert-butyldimethylsilyl)oxy)but-3-en-2-amine

2-[(4-nitrobenzene)sulfonamido]acetic acid

Downstream raw materials:

1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone

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