1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone

Base Information

Chemical Name:1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone
CAS No.:1297141-75-3
Molecular Formula:C₂₀H₃₁N₃O₆SSi
Molecular Weight:469.634
Hs Code.:

Synonyms:1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone

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Chemical Property of 1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone

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Technology Process of 1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone

There total 5 articles about 1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1297141-72-0
N₁-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyI)-2-propen-1-yl]-N₂-[(4-nitrophenyl)sulfonyl]glycinamide

: 106-93-4
ethylene dibromide

: 1297141-75-3
1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1297141-75-3
1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / 2.5 h / 0 °C / pH > 9

1.2: pH 1

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

3.1: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 1297141-75-3
1-[(1S)-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-propen-1-yl]-4-[(4-nitrophenyl)suIfonyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

3: potassium carbonate / N,N-dimethyl-formamide

With 2,6-dimethylpyridine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;