H-PHE-PHE-OME HCL

Base Information

• Chemical Name: H-PHE-PHE-OME HCL
• CAS No.: 38017-65-1
• Molecular Formula: C19H22 N2 O3 . Cl H
• Molecular Weight: 362.856
• Hs Code.: 2924299090
• Mol file: 38017-65-1.mol

Synonyms:Alanine,3-phenyl-N-(3-phenyl-L-alanyl)-, methyl ester, hydrochloride (7CI); L-Phenylalanine,L-phenylalanyl-, methyl ester, monohydrochloride (9CI); L-Phenylalanine,N-L-phenylalanyl-, methyl ester, monohydrochloride;L-Phenylalanyl-L-phenylalanine methyl ester hydrochloride;Phenylalanylphenylalanine methyl ester hydrochloride

Chemical Property of H-PHE-PHE-OME HCL

Chemical Property:

• PSA: 81.42000
• LogP: 3.35010
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

L-Phenylalanyl-L-phenylalanineMethylEsterHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Phenylalanyl-L-phenylalanine Methyl Ester Hydrochloride has been used in the preparation of polymer nanoparticles containing hydrophobic dipeptide for inhibition of amyloid-β fibrillation.

Technology Process of H-PHE-PHE-OME HCL

There total 10 articles about H-PHE-PHE-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropanoate (13122-89-9) → methyl L-phenylalanyl-L-phenylalaninate hydrochloride salt (38017-65-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 2h;

DOI:10.1246/bcsj.67.2478

Reference yield: 98.0%

methanol (67-56-1) + Phe-Phe (2577-40-4) → methyl L-phenylalanyl-L-phenylalaninate hydrochloride salt (38017-65-1)

Guidance literature:

With acetyl chloride; at 0 - 20 ℃;

DOI:10.1021/bm3011177

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → methyl L-phenylalanyl-L-phenylalaninate hydrochloride salt (38017-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N, DCC / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / HCl / ethyl acetate / 2 h / 0 °C

With hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;

DOI:10.1246/bcsj.67.2478

upstream raw materials:

(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropanoate

(S)-3-Phenyl-2-[(S)-3-phenyl-2-((Z)-4,4,4-trifluoro-3-oxo-but-1-enylamino)-propionylamino]-propionic acid methyl ester

N-tert-butoxycarbonyl-L-phenylalanine

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Downstream raw materials:

Bpoc-Asn-Phe-Phe-NHNH₂

Bpoc-Asn-Phe-Phe-Trp-Lys(Boc)-Thr(Bu^t)-OH

Boc-Gly-Pro-Pro-Phe-Phe-NH-NH₂

H-Gly-Pro-Pro-Phe-Phe-NH-NH₂*2HCl