7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

Base Information

Chemical Name:7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine
CAS No.:936558-11-1
Molecular Formula:C₁₆H₁₃ClFN₅O₃
Molecular Weight:377.762
Hs Code.:

Synonyms:7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

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Chemical Property of 7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

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Technology Process of 7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

There total 9 articles about 7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 936558-10-0
2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate

: 936558-11-1
7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

Reference yield: 34.0%

: 936558-11-1
7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

Guidance literature:

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 936558-11-1
7-(2-aminoethoxy)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 5 h / 150 °C

1.2: Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2.5 h / -15 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Cooling with ice

With sodium hydride; trifluoroacetic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;