2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate

Base Information

Chemical Name:2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate
CAS No.:936558-10-0
Molecular Formula:C₂₁H₂₁ClFN₅O₅
Molecular Weight:477.88
Hs Code.:

Synonyms:2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate

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Chemical Property of 2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate

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Technology Process of 2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate

There total 8 articles about 2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 936558-10-0
2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate

Guidance literature:

Reference yield: 60.0%

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 162012-67-1
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

: 936558-10-0
2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate

Guidance literature:: 2-(N-tert-butoxycarbonylamino)ethanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine; In N,N-dimethyl-formamide; for 0.333333h;

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 936558-10-0
2-(4-(3-chloro-4-fluorophenylamino)-6-nitro-quinazolin-7-oxy)ethyl tert-butylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 5 h / 150 °C

1.2: Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2.5 h / -15 - 20 °C / Inert atmosphere

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;