Technology Process of (R)-1-(2,5-dimethoxyphenyl)propan-2-ol
There total 4 articles about (R)-1-(2,5-dimethoxyphenyl)propan-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-2,5-dimethoxybenzene;
With
sec.-butyllithium;
In
tetrahydrofuran; cyclohexane;
at -100 - -90 ℃;
Inert atmosphere;
(R)-propylene oxide;
With
boron trifluoride diethyl etherate;
In
tetrahydrofuran; diethyl ether; cyclohexane;
at -105 - -90 ℃;
With
water; ammonium chloride;
In
tetrahydrofuran; diethyl ether; cyclohexane;
at -90 - 0 ℃;
- Guidance literature:
-
With
1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine; dimethylsulfide borane complex;
In
tetrahydrofuran;
at 25 ℃;
for 2.5h;
Reagent/catalyst;
Temperature;
Overall yield = 95 percent; Overall yield = 935 mg; enantioselective reaction;
Inert atmosphere;
DOI:10.1134/S1070428020040181
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tert-butylamine / toluene / Reflux
2: iron; acetic acid / 3 h / 60 °C
3: dimethylsulfide borane complex; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine / tetrahydrofuran / 2.5 h / 25 °C / Inert atmosphere
With
1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine; dimethylsulfide borane complex; iron; acetic acid; tert-butylamine;
In
tetrahydrofuran; toluene;
2: |Nef Reaction;
DOI:10.1134/S1070428020040181
