1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene

Base Information

Chemical Name:1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene
CAS No.:1031401-04-3
Molecular Formula:C₁₈H₂₃BrF₆O₃
Molecular Weight:481.273
Hs Code.:

Synonyms:1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene

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Chemical Property of 1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene

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Technology Process of 1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene

There total 11 articles about 1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 110-52-1
1,4-dibromo-butane

: 1031393-25-5
4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenol

: 1031401-04-3
1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2015.04.080

Reference yield: 71.0%

: 110-52-1
1,4-dibromo-butane

: 1031400-97-1
4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2,6-di-n-propylphenol

: 1031401-04-3
1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1031401-04-3
1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2: N,N-dimethyl-aniline / 18 h / 210 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 80 °C

5: sodium hydroxide / water; ethanol / 2 h / 0 °C / Reflux

6: thionyl chloride / 2 h / Reflux

7: tetramethylammonium fluoride / 1,2-dimethoxyethane / -78 - 20 °C / Inert atmosphere

8: sodium hydride / tetrahydrofuran / 0 - 20 °C

9: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

10: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With thionyl chloride; palladium 10% on activated carbon; tetramethylammonium fluoride; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-aniline; N,N-dimethyl-formamide; 2: |Claisen Rearrangement;
DOI:10.1016/j.bmcl.2015.04.080