2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane

Base Information

• Chemical Name: 2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane
• CAS No.: 775352-57-3
• Molecular Formula: C₁₅H₂₅BrO₂Si
• Molecular Weight: 345.352
• Mol file: 775352-57-3.mol

Synonyms:2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane

Chemical Property of 2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane

There total 1 articles about 2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-bromophenyl)propan-2-ol (2077-19-2) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane (775352-57-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0960-894X(02)00190-7

Reference yield:

3,4-bis-(difluoromethoxy)-benzaldehyde (127842-54-0) + 2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane (775352-57-3) → [3,4-bis(difluoromethoxy)phenyl]-{4-[2-((2-trimethylsilylethoxy)methoxy)propane-2yl]phenyl}methanol (1055709-54-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran;

DOI:10.1016/S0960-894X(02)00190-7

Reference yield:

2-(4-bromophenyl)-2-[(2-trimethylsilylethoxy)methoxy]propane (775352-57-3) → 3-(3,4-bis-difluoromethoxy-phenyl)-3-{4-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-2-pyridin-4-yl-propionic acid ethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: n-BuLi / tetrahydrofuran

2: SOCl₂; pyridine / toluene / 0 °C

3: KHMDS; HMPA / tetrahydrofuran / 0 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; thionyl chloride; potassium hexamethylsilazane; In tetrahydrofuran; toluene;

DOI:10.1016/S0960-894X(02)00190-7

upstream raw materials:

2-(4-bromophenyl)propan-2-ol

(2-trimethylethylsilylethoxy)methyl chloride

Downstream raw materials:

[3,4-bis(difluoromethoxy)phenyl]-{4-[2-((2-trimethylsilylethoxy)methoxy)propane-2yl]phenyl}methanol

[3,4-bis(difluoromethoxy)phenyl]-{4-[2-((2-trimethylsilylethoxy)methoxy)propane-2-yl]phenyl} chloromethane