Z-LYS(Z)-GLY-OH

Base Information

Chemical Name:Z-LYS(Z)-GLY-OH
CAS No.:37941-54-1
Molecular Formula:C24H29 N3 O7
Molecular Weight:471.5
Hs Code.:2924299090
Mol file:37941-54-1.mol

Synonyms:Glycine,N-(N2,N6-dicarboxy-L-lysyl)-, N2,N6-dibenzyl ester (6CI); Na,Ne-Dibenzyloxycarbonyl-L-lysylglycine

Suppliers and Price of Z-LYS(Z)-GLY-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Nα,Nε-Dibenzyloxycarbonyl-L-lysylglycine
100mg
$ 1160.00

TRC
Nα,Nε-Dibenzyloxycarbonyl-L-lysylglycine
50mg
$ 645.00

American Custom Chemicals Corporation
Z-LYS(Z)-GLY-OH 95.00%
5MG
$ 499.73

Total 2 raw suppliers

Chemical Property of Z-LYS(Z)-GLY-OH

Chemical Property:

Melting Point:158-159 °C
Boiling Point:780.2±60.0 °C(Predicted)
PKA:3.41±0.10(Predicted)
PSA：153.53000
Density:1.262±0.06 g/cm3(Predicted)
LogP:3.82800
Storage Temp.:Store at 0°C
Solubility.:DCM

Purity/Quality:

98%Min ^*data from raw suppliers

Nα,Nε-Dibenzyloxycarbonyl-L-lysylglycine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Nα,Nε-Dibenzyloxycarbonyl-L-lysylglycine intermediate in the synthesis of Avizfone (A794685), the prodrug to Diazepam (D416855), a compound used to treat organophosphate poisoning.

Technology Process of Z-LYS(Z)-GLY-OH

There total 7 articles about Z-LYS(Z)-GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 90970-53-9
Z-L-Lys(Z)-Gly-OBzl

: 37941-54-1
α,ε-Dicarbobenzoxy-L-lysyl-glycine

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 4h;

Reference yield:

: 13567-34-5
N_α,N_ξ-di-Cbz-L-lysylglycine ethyl ester

: 37941-54-1
α,ε-Dicarbobenzoxy-L-lysyl-glycine

Guidance literature:: With sodium hydroxide;
DOI:10.1021/ja01152a519

Reference yield:

: 405-39-0
N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine

: 37941-54-1
α,ε-Dicarbobenzoxy-L-lysyl-glycine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, ethyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 15 min, 2.) THF, CHCl₃, 0 deg C, 1 h; room temp., overnight

2: 90 percent / 1 N NaOH / methanol / 4 h / 0 °C

With 4-methyl-morpholine; sodium hydroxide; chloroformic acid ethyl ester; In methanol;