3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde

Base Information

• Chemical Name: 3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde
• CAS No.: 1401716-02-6
• Molecular Formula: C₁₈H₁₂O₂S
• Molecular Weight: 292.358
• Mol file: 1401716-02-6.mol

Synonyms:3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde

Chemical Property of 3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde

There total 1 articles about 3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-bromobenzo[b]thiophene-2-carbaldehyde (10135-00-9) + 4-methoxyphenylacetylen (768-60-5) → 3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde (1401716-02-6)

Guidance literature:

3-bromobenzo[b]thiophene-2-carbaldehyde; 4-methoxyphenylacetylen; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; for 0.0833333h; Inert atmosphere;

With copper(l) iodide; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201700061

Reference yield: 78.0%

diazoacetic acid ethyl ester (623-73-4) + 3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde (1401716-02-6) → ethyl 3-(3-((4-methoxyphenyl)ethynyl)benzo[b]thiophen-2-yl)-3-oxopropanoate (1401715-94-3)

Guidance literature:

With niobium pentachloride; In dichloromethane; at 25 ℃;

DOI:10.1016/j.tet.2012.08.068

Reference yield: 78.0%

3-((4-methoxyphenyl)ethynyl)benzo[b]thiophene-2-carbaldehyde (1401716-02-6) → 3-(4-methoxyphenyl)benzo[4,5]thieno[2,3-c]pyridine

Guidance literature:

With silver nitrate; tert-butylamine; In ethanol; at 70 ℃; for 36h; regioselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.joc.5b01647

upstream raw materials:

3-bromobenzo[b]thiophene-2-carbaldehyde

4-methoxyphenylacetylen

Downstream raw materials:

ethyl 3-(3-((4-methoxyphenyl)ethynyl)benzo[b]thiophen-2-yl)-3-oxopropanoate

6-(4-methoxyphenyl)benzo[4,5]imidazo[1,2-a]benzo[4,5]thieno[2,3-c]pyridine