1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione

Base Information

Chemical Name:1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione
CAS No.:132143-08-9
Molecular Formula:C₁₆H₂₂N₂O₄Si
Molecular Weight:334.447
Hs Code.:

Synonyms:1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione

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Technology Process of 1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione

There total 1 articles about 1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58594-50-6
3-(2'-nitrophenyl)pyrrolidine-2,5-dione

: 18162-48-6
tert-butyldimethylsilyl chloride

: 132143-08-9
1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione

Guidance literature:: With triethylamine; dmap; In dichloromethane; Yield given; 0 deg C to room temperature;
DOI:10.1016/S0040-4020(01)90540-X

Reference yield: 95.0%

: 132143-08-9
1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione

: 132142-94-0
1-(tert-butyldimethylsilyl)-3-(2'-aminophenyl)pyrrolidine-2,5-dione

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; toluene; for 18h; under 760 Torr;
DOI:10.1016/S0040-4020(01)90540-X

Reference yield:

: 132143-08-9
1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione

: 132143-13-6
(2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / H₂ / 10percent Pd/C / toluene; ethanol / 18 h / 760 Torr

2: toluene / Ambient temperature

3: 1.5 M n-BuLi / 2-methyl-propan-2-ol; tetrahydrofuran; hexane; toluene / 0.5 h / 5 °C

4: toluene

5: 20percent aq. HCl / ethanol / Ambient temperature

6: 98 percent / dimethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature

7: 54 percent / NaBH₄, 2 N H₂SO₄ / ethanol / 0 °C

8: 1.) Et₃N, MeSO₂Cl / 1.) THF, -30 deg C to room temperature, 15 min, 2.) 90 min

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; sulfuric acid; hydrogen; methanesulfonyl chloride; dimethyl azodicarboxylate; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)90540-X