2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile

Base Information

• Chemical Name: 2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile
• CAS No.: 709617-52-7
• Molecular Formula: C₂₀H₁₄N₂O₂
• Molecular Weight: 314.343
• Mol file: 709617-52-7.mol

Synonyms:2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile

Chemical Property of 2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile

There total 4 articles about 2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

α-naphthol (90-15-3) + meta-hydroxybenzaldehyde (100-83-4) + malononitrile (109-77-3) → 2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile (709617-52-7)

Guidance literature:

With 4-dimethylaminopyridine functionalized polyacrylonitrile fiber catalyst; In water; for 1h; Reflux; Green chemistry;

DOI:10.1039/c4ra03985h

Reference yield: 92.0%

α-naphthol (90-15-3) + 3-Hydroxybenzyl alcohol (620-24-6) + malononitrile (109-77-3) → 2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile (709617-52-7)

Guidance literature:

With ammonium cerium (IV) nitrate; 1,2-dimethyl-3-[4-(1,2-dimethyl-1H-imidazol-3-ium-3-yl)butyl]-1H-imidazol-3-ium dibromide; In neat (no solvent); at 20 ℃; for 1h; Milling; Green chemistry;

DOI:10.4067/S0717-97072017000100019

Reference yield:

α-naphthol (90-15-3) + 2-(3-hydroxybenzylidene)malononitrile (7255-96-1) → 2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile (709617-52-7)

Guidance literature:

With dimethyl amine; In ethanol; at 70 ℃; for 0.133333h;

DOI:10.1007/s11164-014-1873-5

upstream raw materials:

α-naphthol

meta-hydroxybenzaldehyde

malononitrile

2-(3-hydroxybenzylidene)malononitrile