methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate

Base Information

• Chemical Name: methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate
• CAS No.: 364782-91-2
• Molecular Formula: C₁₉H₂₃NO₂
• Molecular Weight: 297.397
• Mol file: 364782-91-2.mol

Synonyms:methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate

Chemical Property of methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate

There total 2 articles about methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzyl bromide (100-39-0) + (αS)-methyl N-α-methylbenzyl-3-aminopropanoate (364782-96-7) → methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate (364782-91-2)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1016/S0040-4020(01)00540-3

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate (364782-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / methanol / 3 h / Heating

2: 89 percent / K₂CO₃ / CH₂Cl₂; H₂O / 20 °C

With potassium carbonate; In methanol; dichloromethane; water;

DOI:10.1016/S0040-4020(01)00540-3

Reference yield:

methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate (364782-91-2) + methyl iodide (74-88-4) → methyl N-benzyl-N-[(S)-(1'-phenylethyl)]-(2S)-2-methyl-3-aminopropionate + methyl N-benzyl-N-[(S)-(1'-phenylethyl)]-(2R)-2-methyl-3-aminopropionate

Guidance literature:

methyl (S)-3-[N-benzyl-N-(1'-phenylethyl)]amino propionate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h;

methyl iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 2h;

DOI:10.1016/S0040-4020(01)00540-3

upstream raw materials:

benzyl bromide

(αS)-methyl N-α-methylbenzyl-3-aminopropanoate

(S)-1-phenyl-ethylamine