Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

Base Information

Chemical Name:Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester
CAS No.:357172-89-5
Molecular Formula:C₂₁H₂₂O₄
Molecular Weight:338.403
Hs Code.:

Synonyms:Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

Suppliers and Price of Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

There total 6 articles about Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 357172-88-4
Methoxy-acetic acid 10-[1-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

: 357172-89-5
Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 20 ℃; for 16h;
DOI:10.1016/S0040-4039(01)00708-0

Reference yield:

: 357172-87-3
2-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-deca-3,9-diyn-1-ol

: 357172-89-5
Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / I₂; morpholine / toluene / 18 h / 60 °C

2: 88 percent / PCC; 4 Angstroem MS / CH₂Cl₂ / 20 h / 20 °C

3: 25 percent / CrCl₂; NiCl₂ / tetrahydrofuran / 8 h / 20 °C

4: 71 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

5: 46 percent / PPTS / methanol / 16 h / 20 °C

With morpholine; chromium dichloride; dmap; 4 Angstroem MS; iodine; pyridinium p-toluenesulfonate; dicyclohexyl-carbodiimide; pyridinium chlorochromate; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; toluene; 3: Nozaki-Hiyama-Kishi reaction;
DOI:10.1016/S0040-4039(01)00708-0

Reference yield:

: 357172-76-0
2-[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-meth-(E)-ylidene]-deca-3,9-diynoic acid methyl ester

: 357172-89-5
Methoxy-acetic acid 10-[1-(2-hydroxymethyl-phenyl)-meth-(E)-ylidene]-cyclodeca-2,8-diynyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / Dibal-H / toluene / 1 h / -78 °C

2: 85 percent / I₂; morpholine / toluene / 18 h / 60 °C

3: 88 percent / PCC; 4 Angstroem MS / CH₂Cl₂ / 20 h / 20 °C

4: 25 percent / CrCl₂; NiCl₂ / tetrahydrofuran / 8 h / 20 °C

5: 71 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

6: 46 percent / PPTS / methanol / 16 h / 20 °C

With morpholine; chromium dichloride; dmap; 4 Angstroem MS; iodine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; pyridinium chlorochromate; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; toluene; 4: Nozaki-Hiyama-Kishi reaction;
DOI:10.1016/S0040-4039(01)00708-0