ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate
CAS No.:1445830-97-6
Molecular Formula:C₁₆H₁₈F₂N₂O₄
Molecular Weight:340.327
Hs Code.:

Synonyms:ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate

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Chemical Property of ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate

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Technology Process of ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate

There total 1 articles about ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 759-65-9
diethyl oxalpropionate

: (4-ethoxy-2,6-difluorobenzyl)hydrazine dihydrochloride

: 1445830-97-6
ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate

Guidance literature:: With acetic acid; In 1,4-dioxane; at 90 ℃; for 16h; Inert atmosphere;

Reference yield: 55.7%

: 1445830-97-6
ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate

: 74-88-4
methyl iodide

: 1445831-06-0
ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazole-3-carboxylate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 48h;

Reference yield:

: 1445830-97-6
ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate

: 1445831-09-3
1-(4-ethoxy-2,6-difiuorobenzyl)-5-methoxy-4-methyl-1H-pyrazole-3-carboximidamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 48 h / 20 °C

2: trimethylaluminum; ammonium chloride / n-heptane; toluene / 24 h / 80 °C / Inert atmosphere

With trimethylaluminum; potassium carbonate; ammonium chloride; In n-heptane; acetone; toluene;