methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

Base Information

Chemical Name:methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate
CAS No.:1419172-46-5
Molecular Formula:C₂₅H₂₀O₅S₃
Molecular Weight:496.629
Hs Code.:

Synonyms:methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

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Chemical Property of methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

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Technology Process of methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

There total 4 articles about methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 959627-56-6
methyl 2-(2-{5-[3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

: 98-88-4
benzoyl chloride

: 1419172-46-5
methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

: 1419172-47-6
methyl 2-(5-benzoyl-2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

Guidance literature:: With aluminum (III) chloride; In dichloromethane; for 19h; Inert atmosphere; Sealed tube;

Reference yield:

: 58414-52-1
thiophen-3-yl-acetic acid methyl ester

: 1419172-46-5
methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 72 h / 0 - 20 °C

2: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / toluene; methanol / 1.5 h / 50 °C / Inert atmosphere

3: aluminum (III) chloride / dichloromethane / 19 h / Inert atmosphere; Sealed tube

With aluminum (III) chloride; N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; acetic acid; In methanol; dichloromethane; chloroform; toluene; 2: |Suzuki Coupling;

Reference yield:

: 6964-21-2
thiophen-3-yl-acetic acid

: 1419172-46-5
methyl 2-(2-{5-[5-benzoyl-3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: acetyl chloride / 0 - 20 °C

2: N-Bromosuccinimide; acetic acid / chloroform / 72 h / 0 - 20 °C

3: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / toluene; methanol / 1.5 h / 50 °C / Inert atmosphere

4: aluminum (III) chloride / dichloromethane / 19 h / Inert atmosphere; Sealed tube

With aluminum (III) chloride; N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; acetic acid; acetyl chloride; In methanol; dichloromethane; chloroform; toluene; 3: |Suzuki Coupling;