(2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane

Base Information

Chemical Name:(2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane
CAS No.:858666-78-1
Molecular Formula:C₃₇H₅₆O₃Si₂
Molecular Weight:605.021
Hs Code.:

Synonyms:(2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane

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Chemical Property of (2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane

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Technology Process of (2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane

There total 5 articles about (2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 786668-40-4
(2S,3S)-(-)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-2-methylheptan-3-ol

: 858666-78-1
(2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane

Guidance literature:: With 2,6-dimethylpyridine; dmap; In N,N-dimethyl-formamide;
DOI:10.1021/ol0507975

Reference yield:

: 78999-24-3
5-benzyloxy-1-pentanal

: 858666-78-1
(2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane

Guidance literature:: Multi-step reaction with 4 steps

1.1: TiCl₄; (-)-sparteine / CH₂Cl₂ / 0.33 h / 0 °C

1.2: 90 percent / N-methyl-2-pyrrolidone / CH₂Cl₂ / -78 - 0 °C

2.1: 87 percent / LiBH₄ / tetrahydrofuran / 0.08 h / 20 °C

3.1: 77 percent / imidazole / CH₂Cl₂ / 20 h / 20 °C

4.1: 95 percent / 4-(dimethylamino)pyridine; 2,6-lutidine / dimethylformamide / 20 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; dmap; lithium borohydride; titanium tetrachloride; (-)-sparteine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b600951d

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 858666-78-1
(2S,3S)-(+)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-3-tert-butyldimethylsilyloxy-2-methylheptane

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / imidazole / CH₂Cl₂ / 20 h / 20 °C

2: 95 percent / 4-(dimethylamino)pyridine; 2,6-lutidine / dimethylformamide / 20 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; dmap; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b600951d