(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Base Information

Chemical Name:(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester
CAS No.:188259-73-6
Molecular Formula:C₅₈H₈₇NO₅SSi₃
Molecular Weight:994.655
Hs Code.:

(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Synonyms:(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Suppliers and Price of (3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

There total 9 articles about (3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 994-30-9
triethylsilyl chloride

: 188259-68-9
(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8-tetramethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

: 188259-73-6
(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1021/ja964275j

Reference yield:

: 186692-60-4
(2R,3R,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptanal

: 188259-73-6
(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / diethyl ether / -78 - 0 °C

3: LDA / tetrahydrofuran / -78 °C

5: NaBH₄

6: 80 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 1: Grignard reaction / 3: Condensation / 4: Oxidation / 5: Reduction / 6: silylation;
DOI:10.1021/ja964275j

Reference yield:

: 184246-38-6
(E)-2-methyl-3-(2-methylthiazol-4-yl)acrylaldehyde

: 188259-73-6
(3S,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-3-triethylsilanyloxy-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: (S)-(-)-BINOL; Ti(Oi-Pr)4 / CH₂Cl₂ / -20 °C

2: 95 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 20 °C

3: LDA / tetrahydrofuran / -78 °C

5: NaBH₄

6: 80 percent / imidazole / dimethylformamide

With 1H-imidazole; titanium(IV) isopropylate; dmap; sodium tetrahydroborate; (S)-[1,1']-binaphthalenyl-2,2'-diol; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: allylation / 2: Acetylation / 3: Condensation / 4: Oxidation / 5: Reduction / 6: silylation;
DOI:10.1021/ja964275j