methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

Base Information

• Chemical Name: methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate
• CAS No.: 853181-29-0
• Molecular Formula: C₁₉H₂₁FN₂O₂
• Molecular Weight: 328.386

Synonyms:methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

Chemical Property of methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

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Technology Process of methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

There total 1 articles about methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 4-(4-fluorophenyl)-2-isopropyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate (853181-52-9) → methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate (853181-29-0)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 2.33333 - 3h; Product distribution / selectivity;

Reference yield: 88.0%

methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate (853181-29-0) → (4-(4-fluorophenyl)-2-(1-methylethyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methanol (853181-94-9)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 - -25 ℃; for 3 - 4h;

Reference yield: 85.0%

methyl 4-(4-fluorophenyl)-2-isopropyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate (853181-29-0) + Methanesulfonic anhydride (7143-01-3) → methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate (853181-27-8)

Guidance literature:

With 3,5-Lutidine; In dichloromethane; toluene; at 20 ℃; for 72h; Product distribution / selectivity;

upstream raw materials:

methyl 4-(4-fluorophenyl)-2-isopropyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

Downstream raw materials:

methyl 4-(4-fluorophenyl)-2-isopropyl-8-methanesulfonyl-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

methyl 8-(1-chloroethylsulfonyl)-4-(4-fluorophenyl)-2-(1-methylethyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxylate

(4-(4-fluorophenyl)-2-(1-methylethyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methanol

methyl 8-(2-chloropropan-2-ylsulfonyl)-4-(4-fluorophenyl)-2-(1-methylethyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxylate

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