3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one

Base Information

• Chemical Name: 3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one
• CAS No.: 698348-05-9
• Molecular Formula: C₁₆H₁₇F₅OS₂
• Molecular Weight: 384.434
• Mol file: 698348-05-9.mol

Synonyms:3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one

Chemical Property of 3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one

There total 2 articles about 3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Bis(ethylthio)(1,2,2,3,3,3-hexafluoropropylidene)methane (145327-77-1) + acetophenone (98-86-2) → 3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one (698348-05-9)

Guidance literature:

With potassium hydride; In tetrahydrofuran; at 0 - 25 ℃; for 10h;

DOI:10.1055/s-2004-815970

Reference yield:

Bis(ethylthio)(heptafluoropropyl)methane (145327-73-7) → 3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one (698348-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; tetrabutylammomium bromide / dichloromethane; water

2: potassium hydride / tetrahydrofuran / 0 °C

With tetrabutylammomium bromide; potassium hydride; potassium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jm301076q

Reference yield: 85.0%

3-(Bis-ethylsulfanyl-methylene)-4,4,5,5,5-pentafluoro-1-phenyl-pentan-1-one (698348-05-9) → S-ethyl 3,3,4,4,4-pentafluoro-2-(2-oxo-2-phenylethyl)butanethioate (698348-08-2)

Guidance literature:

With trifluoroacetic acid; for 10h; Heating;

DOI:10.1055/s-2004-815970

upstream raw materials:

Bis(ethylthio)(1,2,2,3,3,3-hexafluoropropylidene)methane

acetophenone

Bis(ethylthio)(heptafluoropropyl)methane

Downstream raw materials:

S-ethyl 3,3,4,4,4-pentafluoro-2-(2-oxo-2-phenylethyl)butanethioate

C₂₆H₂₅ClF₃N₃O₂S

C₂₉H₃₁ClF₃N₃O₂S