S(+)-N-tert-butyl-O-acetyl mandelamid

Base Information

Chemical Name:S(+)-N-tert-butyl-O-acetyl mandelamid
CAS No.:469874-36-0
Molecular Formula:C₁₄H₁₉NO₃
Molecular Weight:249.31
Hs Code.:

Synonyms:S(+)-N-tert-butyl-O-acetyl mandelamid

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Chemical Property of S(+)-N-tert-butyl-O-acetyl mandelamid

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Technology Process of S(+)-N-tert-butyl-O-acetyl mandelamid

There total 3 articles about S(+)-N-tert-butyl-O-acetyl mandelamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 7322-88-5
(S)-acetylmandelic acid

: 75-64-9
tert-butylamine

: 469874-36-0
S(+)-N-tert-butyl-O-acetyl mandelamid

Guidance literature:: (S)-acetylmandelic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; copper dichloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

tert-butylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;
DOI:10.1016/S0040-4020(02)00376-9

Reference yield: 86.0%

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 100-52-7
benzaldehyde

: 64-19-7,77671-22-8
acetic acid

: 469874-36-0
S(+)-N-tert-butyl-O-acetyl mandelamid

Guidance literature:: benzaldehyde; acetic acid; With choline chloride; urea; at 20 ℃; for 0.166667h; Green chemistry;

tert-butylisonitrile; at 20 ℃; for 20h; enantioselective reaction; Green chemistry;
DOI:10.1039/d1ra05297g

Reference yield:

: 17199-29-0
(S)-Mandelic acid

: 469874-36-0
S(+)-N-tert-butyl-O-acetyl mandelamid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / 20 °C

2.1: anhydrous CuCl₂; 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / dimethylformamide / 0.5 h / 0 - 20 °C

2.2: 86 percent / dimethylformamide / 24 h / 0 - 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; copper dichloride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00376-9