(R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide

Base Information

Chemical Name:(R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide
CAS No.:1450908-81-2
Molecular Formula:C₂₆H₂₅N₃O₂
Molecular Weight:411.503
Hs Code.:

Synonyms:(R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide

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Chemical Property of (R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide

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Technology Process of (R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide

There total 4 articles about (R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1450909-02-0
(E)-N-benzyl-2-(2-(4-methoxyphenyl)hydrazono)acetamide

: 122-57-6
1-Phenylbut-1-en-3-one

: 1450908-81-2
(R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide

Guidance literature:: With (S)-N¹-cyclohexyl-3,3-dimethylbutane-1,2-diamine; o-fluoro-benzoic acid; at 20 ℃; for 72h; enantioselective reaction;
DOI:10.1021/ol4020865

Reference yield:

: 313266-11-4
N¹,N⁴-dibenzyl-2,3-dihydroxysuccinamide

: 1450908-81-2
(R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: periodic acid / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 0 - 20 °C

3: o-fluoro-benzoic acid; (S)-N¹-cyclohexyl-3,3-dimethylbutane-1,2-diamine / 72 h / 20 °C

With (S)-N¹-cyclohexyl-3,3-dimethylbutane-1,2-diamine; periodic acid; triethylamine; o-fluoro-benzoic acid; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol4020865

Reference yield:

: 32331-52-5
N-benzyl glyoxylic amide

: 1450908-81-2
(R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: o-fluoro-benzoic acid; (S)-N¹-cyclohexyl-3,3-dimethylbutane-1,2-diamine / 72 h / 20 °C

With (S)-N¹-cyclohexyl-3,3-dimethylbutane-1,2-diamine; triethylamine; o-fluoro-benzoic acid; In tetrahydrofuran;
DOI:10.1021/ol4020865