3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Base Information

Chemical Name:3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole
CAS No.:950482-50-5
Molecular Formula:C₁₈H₁₄Cl₃F₃N₂O
Molecular Weight:437.676
Hs Code.:

Synonyms:3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

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Chemical Property of 3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Chemical Property:

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Technology Process of 3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

There total 12 articles about 3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 950482-50-5
3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: N-chloro-succinimide / 1,2-dimethoxyethane / 2 h / 70 °C

2.2: 20 h / 20 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 3 h / 70 °C

4.1: acetic acid / 2 h / 120 °C

4.2: 20 °C

5.1: sodium hydroxide; ethanol; water / 1 h / 100 °C

6.1: pyridinium chlorochromate / dichloromethane / 20 h / 20 °C

7.1: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C / Heating / reflux

7.2: 0 °C

8.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

9.1: N,N-dimethyl-formamide / 1.5 h / 100 °C

10.1: hydrazine / ethanol; water / 1 h / Heating / reflux

With sodium hydroxide; N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); ethanol; water; potassium carbonate; acetic acid; pyridinium chlorochromate; hydrazine; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 950482-71-0
N-[1-[2-chloro-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] phenyl] ethyl] phthalimide

: 950482-50-5
3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: With hydrazine; In ethanol; water; for 1h; Heating / reflux;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 950482-50-5
3-[3-chloro-4-(1-aminoethyl) phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-chloro-succinimide / 1,2-dimethoxyethane / 2 h / 70 °C

1.2: 20 h / 20 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 3 h / 70 °C

3.1: acetic acid / 2 h / 120 °C

3.2: 20 °C

4.1: sodium hydroxide; ethanol; water / 1 h / 100 °C

5.1: pyridinium chlorochromate / dichloromethane / 20 h / 20 °C

6.1: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C / Heating / reflux

6.2: 0 °C

7.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

8.1: N,N-dimethyl-formamide / 1.5 h / 100 °C

9.1: hydrazine / ethanol; water / 1 h / Heating / reflux

With sodium hydroxide; N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); ethanol; water; acetic acid; pyridinium chlorochromate; hydrazine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;