(2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide

Base Information

Chemical Name:(2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide
CAS No.:871822-60-5
Molecular Formula:C₂₈H₃₀N₈O₇S
Molecular Weight:622.662
Hs Code.:

Synonyms:(2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide

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Chemical Property of (2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide

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Technology Process of (2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide

There total 19 articles about (2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 731015-35-3
2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

: 57471-69-9
L-asparaginamide hydrochloride

: 871822-60-5
(2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide

Guidance literature:: 2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid; With 2,3,5-trimethyl-pyridine; HATU; In dimethyl amine; for 2h;

L-asparaginamide hydrochloride; With triethylamine; In dimethyl amine;

Reference yield:

: 74138-37-7
4-amino-3-nitrobenzamidine monohydrochloride

: 871822-60-5
(2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium hydroxide on carbon / methanol / 1.5 h / 2585.81 Torr

2: p-benzoquinone / methanol / Heating / reflux

3: trifluoroacetic acid / 1 h

4: pyridine hydrochloride / 3 h / 180 °C

5: 2,3,5-trimethyl-pyridine; HATU / dimethyl amine / 2 h

With 2,3,5-trimethyl-pyridine; hydrogen; pyridine hydrochloride; HATU; trifluoroacetic acid; p-benzoquinone; palladium hydroxide on carbon; In methanol; dimethyl amine;

Reference yield:

: 731015-44-4
methyl 2-(3-formyl-4-hydroxyphenyl)-2-methylpropanoate

: 871822-60-5
(2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide / DMF (N,N-dimethyl-formamide) / 3 h / 5 - 20 °C

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3.5 h / 20 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; water; toluene / 3 h / Heating / reflux

4: p-benzoquinone / methanol / Heating / reflux

5: trifluoroacetic acid / 1 h

6: pyridine hydrochloride / 3 h / 180 °C

7: 2,3,5-trimethyl-pyridine; HATU / dimethyl amine / 2 h

With 2,3,5-trimethyl-pyridine; N-Bromosuccinimide; pyridine hydrochloride; potassium carbonate; HATU; trifluoroacetic acid; p-benzoquinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; DMF (N,N-dimethyl-formamide); water; dimethyl amine; toluene;