2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

Base Information

Chemical Name:2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid
CAS No.:731015-35-3
Molecular Formula:C₂₄H₂₃N₅O₆S
Molecular Weight:509.543
Hs Code.:

Synonyms:2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

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Chemical Property of 2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

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Technology Process of 2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

There total 18 articles about 2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-tert-butylsulfamoylbiphenyl-3-yl]-2-methylpropionate

: 731015-35-3
2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

Guidance literature:: methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-tert-butylsulfamoylbiphenyl-3-yl]-2-methylpropionate; With trifluoroacetic acid; for 1.5h;

With pyridine hydrochloride; at 180 ℃; for 3h;

Reference yield:

: methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionate

: 731015-35-3
2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

Guidance literature:: With pyridine hydrochloride; at 180 ℃; for 3h;

Reference yield:

: 731015-44-4
methyl 2-(3-formyl-4-hydroxyphenyl)-2-methylpropanoate

: 731015-35-3
2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / DMF (N,N-dimethyl-formamide) / 3 h / 5 - 20 °C

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3.5 h / 20 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; water; toluene / 3 h / Heating / reflux

4: p-benzoquinone / methanol / Heating / reflux

5: trifluoroacetic acid / 1 h

6: pyridine hydrochloride / 3 h / 180 °C

With N-Bromosuccinimide; pyridine hydrochloride; potassium carbonate; trifluoroacetic acid; p-benzoquinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; DMF (N,N-dimethyl-formamide); water; toluene;