methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate

Base Information

Chemical Name:methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate
CAS No.:1616290-46-0
Molecular Formula:C₁₉H₂₃BrN₂O₄
Molecular Weight:423.307
Hs Code.:

Synonyms:methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate

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Chemical Property of methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate

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Technology Process of methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate

There total 10 articles about methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1173081-96-3
(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methylamine hydrochloride

: 1616290-44-8
methyl 3-bromo-2-methyl-6-(2-oxoethoxy)benzoate

: 1616290-46-0
methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate

Guidance literature:: (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methylamine hydrochloride; methyl 3-bromo-2-methyl-6-(2-oxoethoxy)benzoate; In methanol; at 20 ℃; for 0.5h; Sonication;

With sodium cyanoborohydride; In methanol; for 3h;

Reference yield:

: 99548-54-6
methyl 3-bromo-2-methylbenzoate

: 1616290-46-0
methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dipotassium peroxodisulfate; trifluoroacetic acid / dichloromethane; trifluoroacetic anhydride / 85 °C / Sealed tube

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 55 °C

3.1: hydrogenchloride / methanol / 0.5 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

5.1: methanol / 0.5 h / 20 °C / Sonication

5.2: 3 h

With hydrogenchloride; dipotassium peroxodisulfate; caesium carbonate; Dess-Martin periodane; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; trifluoroacetic anhydride;

Reference yield:

: 603041-59-4
methyl 3-bromo-6-hydroxy-2-methylbenzoate

: 1616290-46-0
methyl 3-bromo-6-(2-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]amino}ethoxy)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 55 °C

2.1: hydrogenchloride / methanol / 0.5 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: methanol / 0.5 h / 20 °C / Sonication

4.2: 3 h

With hydrogenchloride; caesium carbonate; Dess-Martin periodane; In methanol; dichloromethane; N,N-dimethyl-formamide;