2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:1026046-79-6
Molecular Formula:C₂₀H₂₇F₃O₂
Molecular Weight:356.428
Hs Code.:

Synonyms:2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of 2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of 2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

There total 4 articles about 2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15356-60-2
(1S,2R,5S)-(+)-menthol

: 1026046-79-6
2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / 40 °C

2: 1.) NaNH₂ / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min

With sodium amide; In dichloromethane;
DOI:10.1021/jm00037a022

Reference yield:

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1026046-79-6
2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 1 h / 60 °C

2: CH₂Cl₂ / 1 h / 40 °C

3: 1.) NaNH₂ / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min

With thionyl chloride; sodium amide; In dichloromethane;
DOI:10.1021/jm00037a022

Reference yield:

: 74426-51-0
4-(trifluoromethyl)phenylacetyl chloride

: 1026046-79-6
2-(4-Trifluoromethyl-phenyl)-propionic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / 40 °C

2: 1.) NaNH₂ / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min

With sodium amide; In dichloromethane;
DOI:10.1021/jm00037a022