2,2,2-TRICHLORO-1,1-DIMETHYLETHYL DICHLOROPHOSPHITE

Base Information

• Chemical Name: 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL DICHLOROPHOSPHITE
• CAS No.: 39177-74-7
• Molecular Formula: C4H6 Cl5 O P
• Molecular Weight: 278.33
• Hs Code.: 2909199090
• Mol file: 39177-74-7.mol

Synonyms:2,2,2-TRICHLORO-1,1-DIMETHYLETHYL DICHLOROPHOSPHITE

Chemical Property of 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL DICHLOROPHOSPHITE

Chemical Property:

• Vapor Pressure: 0.0757mmHg at 25°C
• Boiling Point: 235.7°C at 760 mmHg
• Flash Point: 96.3°C
• PSA: 22.82000
• Density: 1.528 g/mL at 25 °C(lit.)
• LogP: 4.85630

Purity/Quality:

99% ^*data from raw suppliers

2,2,2-TRICHLORO-1,1-DIMETHYLETHYL DICHLOROPHOSPHITE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 20/21/22-34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL DICHLOROPHOSPHITE

There total 1 articles about 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL DICHLOROPHOSPHITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,1,1-trichloro-2-methyl-2-propanol (57-15-8) → 2,2,2-trichloro-1,1-dimethylethyldichloro phosphite (39177-74-7)

Guidance literature:

With pyridine; phosphorus trichloride; In pentane; 1.) 1 d, 21 deg C, 2.) 2 h, reflux;

Reference yield: 70.0%

2,2,2-trichloro-1,1-dimethylethyldichloro phosphite (39177-74-7) + 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine (42926-80-7) + thymin (65-71-4,28806-14-6,691841-57-3) → 1,1-dimethyl-2,2,2-trichloroethyl 5'-O-momo-p-methoxytritylthymidyl-3' thymidyl-5 phosphite (90813-75-5)

Guidance literature:

In tetrahydrofuran; pyridine; 1.) -78 deg C, 15 min; 2.) -78 deg C, 15 min, warmed to 0 deg C over 15 min;

DOI:10.1016/0040-4020(84)85112-1

Reference yield: 69.0%

2,2,2-trichloro-1,1-dimethylethyldichloro phosphite (39177-74-7) + 1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-glycerol (142350-43-4) + methyl N-trityl-L-serinate (13515-76-9,116457-91-1,4465-44-5) → 1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-glyceryl 2,2,2-trichloro-tert-butyl 2-carbomethoxy-2-(N-triphenylmethylamino)ethyl phosphite (257887-94-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(00)74193-1

upstream raw materials:

1,1,1-trichloro-2-methyl-2-propanol

Downstream raw materials:

chloro-(2,2,2-trichloro-1,1-dimethyl-ethoxy)-(1-trichloromethyl-cyclohexyloxy)-phosphine

phosphorous acid dicyclohexyl ester-(2,2,2-trichloro-1,1-dimethyl-ethyl ester)

phosphorous acid diphenyl ester-(2,2,2-trichloro-1,1-dimethyl-ethyl ester)

C₄₉H₅₅Cl₇N₄O₁₅P₂

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