Technology Process of (S,S)-α-methyl-β-phenylalanine
There total 13 articles about (S,S)-α-methyl-β-phenylalanine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol;
With
sulfuric acid; water; periodic acid;
In
acetonitrile;
at 20 ℃;
for 16h;
With
sodium dichromate;
In
acetonitrile;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 0.5 h / -78 °C
2.1: Ti(O-i-Pr)4; i-Pr2NEt; 4 Angstroem molecular sieves / TiCl4 / CH2Cl2 / 0.5 h / 0 °C
2.2: 50 percent / CH2Cl2 / -78 - 20 °C
3.1: Zn; AcOH
4.1: LiOH
5.1: H2 / Pd/C
With
titanium(IV) isopropylate; lithium hydroxide; 4 A molecular sieve; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; zinc;
palladium on activated charcoal; titanium tetrachloride;
In
dichloromethane;
DOI:10.1021/ol9905755
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Ti(O-i-Pr)4; i-Pr2NEt; 4 Angstroem molecular sieves / TiCl4 / CH2Cl2 / 0.5 h / 0 °C
1.2: 50 percent / CH2Cl2 / -78 - 20 °C
2.1: Zn; AcOH
3.1: LiOH
4.1: H2 / Pd/C
With
titanium(IV) isopropylate; lithium hydroxide; 4 A molecular sieve; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; zinc;
palladium on activated charcoal; titanium tetrachloride;
In
dichloromethane;
DOI:10.1021/ol9905755