(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol

Base Information

• Chemical Name: (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol
• CAS No.: 605683-32-7
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.359
• Mol file: 605683-32-7.mol

Synonyms:(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol

Chemical Property of (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol

There total 15 articles about (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl(4-methoxyphenyl)amine (17377-95-6) + propionaldehyde (123-38-6) → (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol (605683-32-7)

Guidance literature:

benzyl(4-methoxyphenyl)amine; With [C₅(Ph₄)-O-Ru(CO)2]2 ruthenium; 2,6-dimethoxy-p-quinone; oxygen; [C₆H₄-O-2-CH=N-CH₂N(Me)CH₂-N=CH-C₆H₄-2-O]*Co; In toluene; at 110 ℃; for 24h;

propionaldehyde; With 1-methyl-pyrrolidin-2-one; L-proline; at -20 ℃; for 16h;

With sodium tetrahydroborate; In methanol; at 0 ℃;

DOI:10.1016/j.tetlet.2005.04.047

Reference yield: 85.0%

benzaldehyde (100-52-7) + 4-methoxy-aniline (104-94-9) + propionaldehyde (123-38-6) → (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol (605683-32-7)

Guidance literature:

With sodium tetrahydroborate; L-proline; In 1-methyl-pyrrolidin-2-one; at -10 ℃; for 20h; Further Variations:; Temperatures; Kinetics;

DOI:10.1002/adsc.200505190

Reference yield: 28.0%

propionaldehyde (123-38-6) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-phenylpropan-1-ol (605683-32-7)

Guidance literature:

benzaldehyde; 4-methoxy-aniline; In 1-methyl-pyrrolidin-2-one; for 1.5h;

propionaldehyde; L-proline; In 1-methyl-pyrrolidin-2-one; at -20 ℃; for 40.5h;

With hydrogenchloride; sodium tetrahydroborate; more than 3 stages;

upstream raw materials:

propionaldehyde

4-methoxy-N-[(E)-phenylmethylidene]aniline

benzyl(4-methoxyphenyl)amine

benzaldehyde

Downstream raw materials:

p-benzoquinone

(S,S)-α-methyl-β-phenylalanine

(2S,3R)-1-(4-methoxyphenyl)-3-methyl-2-phenylazetidine