1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI)

Base Information

• Chemical Name: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI)
• CAS No.: 366453-22-7
• Molecular Formula: C9H9 N O2
• Molecular Weight: 163.17
• Hs Code.: 2933790090
• Mol file: 366453-22-7.mol

Synonyms:4-Methoxy-2,3-dihydroisoindol-1-one

Chemical Property of 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI)

Chemical Property:

• Melting Point: >200 °C
• Boiling Point: 439.2±45.0 °C(Predicted)
• PKA: 14.37±0.20(Predicted)
• PSA: 41.82000
• Density: 1.208±0.06 g/cm3(Predicted)
• LogP: 0.94900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

4-Methoxyisoindolin-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI)

There total 12 articles about 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-(bromomethyl)-3-methoxybenzoate (71887-28-0) → 4-methoxyisoindolin-1-one (366453-22-7)

Guidance literature:

With methanol; ammonia; for 2h; Reflux;

DOI:10.1016/j.cclet.2011.10.002

Reference yield: 92.0%

N,N-diisopropyl-2-(4-methoxy-1-oxoisoindolin-2-yl)-2-oxoacetamide → 4-methoxyisoindolin-1-one (366453-22-7)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 4h;

DOI:10.1021/acs.joc.7b00975

Reference yield: 82.0%

N'-(2-methoxybenzyl)-N,N-dimethylurea → 4-methoxyisoindolin-1-one (366453-22-7)

Guidance literature:

N'-(2-methoxybenzyl)-N,N-dimethylurea; With tert.-butyl lithium; In tetrahydrofuran; n-heptane; at 0 ℃; for 6h; Inert atmosphere;

With water; In tetrahydrofuran; n-heptane; at 0 - 20 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; diethyl ether; n-heptane; at 20 ℃; Inert atmosphere;

DOI:10.1039/b926983e

upstream raw materials:

methyl 2-(bromomethyl)-3-methoxybenzoate

3-methoxy-2-methylbenzoic acid methyl ester

3-methoxy-2-methylbenzoic acid

2-methoxybenzylamine

Downstream raw materials:

C₁₉H₁₉NO₄

4-hydroxyisoindolin-1-one

Refernces

• 1、 Andrade-Sampedro, Paula,Matxain, Jon M.,Correa, Arkaitz. "Pd-Catalyzed C(sp2)?H Alkoxycarbonylation of Phenethyl- and Benzylamines with Chloroformates as CO Surrogates". . p. 5782 - 5789. Retrieved 2021.
• 2、 Fu, Li Qiang,Ling, Chen Yu,Guo, Xing Sheng,He, Hui Li,Yang, Yu She. "Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain". scheme or table. p. 9 - 12. Retrieved 2012/03/27.