1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid

Base Information

Chemical Name:1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid
CAS No.:1105064-58-1
Molecular Formula:C₂₇H₃₃NO₇
Molecular Weight:483.562
Hs Code.:

Synonyms:1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid

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Chemical Property of 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid

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Technology Process of 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid

There total 2 articles about 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 108-30-5
succinic acid anhydride

: 1105064-57-0
(RS) 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline

: 1105064-58-1
1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.tet.2008.10.052

Reference yield:

: 1105064-42-3
2-(trifluoroacetyl)-1,2,3,4-tetrahydro-1-(4',5'-dimethoxy-2'-(2''-propenyl)phenyl)methyl-6,7-dimethoxyisoquinoline

: 1105064-58-1
1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol; water / 18 h / 20 °C

2: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; In methanol; dichloromethane; water;
DOI:10.1016/j.tet.2009.05.094

Reference yield: 82.0%

: 1105064-58-1
1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4',5'-dimethoxy-2'-(2-propenyl)phenyl)methylisoquinoline 2-(4-oxo)butanoic acid

: 59444-59-6
(+/-)-1-(2-bromo-4,5-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1105064-59-2
C₄₇H₅₅BrN₂O₁₀

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.tet.2008.10.052