Technology Process of 3-(2-{[3-(4-chlorophenyl)pyridin-2-yl]oxy}ethyl)-9-methyl-9H-pyrido[2,3-b]indole
There total 9 articles about 3-(2-{[3-(4-chlorophenyl)pyridin-2-yl]oxy}ethyl)-9-methyl-9H-pyrido[2,3-b]indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate;
In
water; dimethyl sulfoxide;
at 80 ℃;
for 16h;
Inert atmosphere;
Schlenk technique;
DOI:10.1016/j.bmcl.2014.03.054
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Schlenk technique
4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
4.2: 3 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
5.1: caesium carbonate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere; Schlenk technique
6.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide; water / 16 h / 80 °C / Inert atmosphere; Schlenk technique
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium tert-butylate; diisobutylaluminium hydride; sodium carbonate; potassium carbonate; caesium carbonate; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
3.1: |Wittig Olefination / 6.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.03.054
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Schlenk technique
2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.2: 3 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
3.1: caesium carbonate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere; Schlenk technique
4.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide; water / 16 h / 80 °C / Inert atmosphere; Schlenk technique
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium tert-butylate; sodium carbonate; caesium carbonate; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran; water; dimethyl sulfoxide;
1.1: |Wittig Olefination / 4.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.03.054
