4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Base Information

Chemical Name:4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
CAS No.:1287312-54-2
Molecular Formula:C₁₅H₁₆N₂O₄S
Molecular Weight:320.369
Hs Code.:

Synonyms:4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

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Technology Process of 4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

There total 7 articles about 4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.4%

: 1287312-48-4
7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

: 124-63-0
methanesulfonyl chloride

: 1287312-54-2
4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 144h;
DOI:10.1016/j.bmcl.2011.01.027

Reference yield:

: 1287312-62-2
tert-butyl 7-formyl-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

: 1287312-54-2
4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 0.25 h

2: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 18 h

3: hydrogenchloride / water

4: pyridine / dichloromethane / 144 h / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; water; toluene; 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.01.027

Reference yield:

: 34950-82-8
7-bromo-3,4-dihydro-2H-pyrido[3,2-β][1,4]oxazine

: 1287312-54-2
4-(methylsulfonyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Guidance literature:: Multi-step reaction with 7 steps

1: 18 h / 50 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 4 h / 85 °C

3: sodium periodate; osmium(VIII) oxide; tert-butyl alcohol / tetrahydrofuran; water / 1 h / 20 °C

4: sodium tetrahydroborate / methanol / 0.25 h

5: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 18 h

6: hydrogenchloride / water

7: pyridine / dichloromethane / 144 h / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triphenylphosphine; tert-butyl alcohol; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 5: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.01.027