(RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol

Base Information

Chemical Name:(RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol
CAS No.:374819-25-7
Molecular Formula:C₂₅H₂₆F₆O₄
Molecular Weight:504.469
Hs Code.:

Synonyms:(RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol

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Chemical Property of (RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol

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Technology Process of (RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol

There total 6 articles about (RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374819-22-4
1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethenyl}-3,5-bis(trifluoromethyl)benzene

: 374819-25-7
(RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol

Guidance literature:: 1-{1-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]ethenyl}-3,5-bis(trifluoromethyl)benzene; With borane-THF; In tetrahydrofuran; at 20 ℃;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

: 51510-00-0
(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)methanol

: 374819-25-7
(RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 20 °C

2.1: toluene / 90 °C

3.1: BH₃*THF / tetrahydrofuran / 20 °C

3.2: H₂O₂; aq. NaOH / tetrahydrofuran / 20 °C

With borane-THF; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

: 51509-98-9
8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonitril

: 374819-25-7
(RS)-β-[(1,4-dioxa-8-phenylspiro[4.5]decan-8-yl)methoxy]-3,5-bis(trifluoromethyl) benzeneethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: DIBAL-H / toluene / -78 °C

1.2: NaBH₄; EtOH

2.1: CH₂Cl₂ / 20 °C

3.1: toluene / 90 °C

4.1: BH₃*THF / tetrahydrofuran / 20 °C

4.2: H₂O₂; aq. NaOH / tetrahydrofuran / 20 °C

With borane-THF; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0960-894X(02)00249-4