6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE

Base Information

• Chemical Name: 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE
• CAS No.: 364793-54-4
• Molecular Formula: C10H4BrClN2
• Molecular Weight: 267.512
• Mol file: 364793-54-4.mol

Synonyms:6-Bromo-4-chloro-3-quinolinecarbonitrile;6-Bromo-4-chloroquinoline-3-carbonitrile;

Chemical Property of 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 146 - 148 °C
• Refractive Index: 1.711
• Boiling Point: 401.866 °C at 760 mmHg
• PKA: -0.52±0.27(Predicted)
• Flash Point: 196.842 °C
• Density: 1.76 g/cm³

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-4-chloroquinoline-3-carbonitrile 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE

There total 7 articles about 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-4-hydroxyquinoline-3-carbonitrile (364793-52-2,958649-15-5) → 6-bromo-4-chloro-3-quinolinecarbonitrile (364793-54-4)

Guidance literature:

DOI:10.1016/j.bmcl.2006.08.102

Reference yield:

6-bromo-4-oxo-1,4-dihydroquinoline-3-carbonitrile (364793-52-2,958649-15-5) → 6-bromo-4-chloro-3-quinolinecarbonitrile (364793-54-4)

Guidance literature:

With trichlorophosphate;

DOI:10.1016/S0960-894X(02)00302-5

Reference yield:

4-bromo-aniline (106-40-1) → 6-bromo-4-chloro-3-quinolinecarbonitrile (364793-54-4)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: dowtherm / 4 h / 260 °C

3: trichlorophosphate / 3 h / 100 °C

With caesium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;

upstream raw materials:

6-bromo-4-oxo-1,4-dihydroquinoline-3-carbonitrile

6-bromo-4-hydroxyquinoline-3-carbonitrile

ethyl (Z)-3-[(4-bromophenyl)amino]-2-cyanoprop-2-enoate

4-bromo-aniline

Downstream raw materials:

6-bromo-4-(2,4-dichloro-5-methoxyanilino)-3-quinolinecarbonitrile

6-bromo-4-((3,4,5-trimethoxyphenyl)amino)quinoline-3-carbonitrile

6-bromo-N-(3-chloro-4-fluoro-phenyl)-quinoline-3-carbnitrile-4-amine

4-(3-Chloro-4-fluoro-phenylamino)-6-((E)-styryl)-quinoline-3-carbonitrile