(8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol

Base Information

• Chemical Name: (8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol
• CAS No.: 118738-57-1
• Molecular Formula: C₁₅H₁₄N₂O₂
• Molecular Weight: 254.288
• Mol file: 118738-57-1.mol

Synonyms:(8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol

Chemical Property of (8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol

There total 1 articles about (8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

pyridoxamine (85-87-0) + orthobenzoic acid trimethyl ester (707-07-3) → (8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol (118738-57-1)

Guidance literature:

In N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1016/S0040-4020(01)86057-9

Reference yield: 68.0%

(8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol (118738-57-1) → 8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazine-5-carbaldehyde (118738-58-2)

Guidance literature:

With barium manganate; In dichloromethane; for 6h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86057-9

Reference yield:

(8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol (118738-57-1) → 4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol (118777-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / barium manganate / CH₂Cl₂ / 6 h / Ambient temperature

2: 85 percent / 1.) Mg, ethylene dibromide / tetrahydrofuran / 2 h

With barium manganate; magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(01)86057-9

upstream raw materials:

pyridoxamine

orthobenzoic acid trimethyl ester

Downstream raw materials:

8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazine-5-carbaldehyde

4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol

Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester