4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol

Base Information

• Chemical Name: 4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol
• CAS No.: 118777-78-9
• Molecular Formula: C₂₀H₂₅N₃O₂
• Molecular Weight: 339.437
• Mol file: 118777-78-9.mol

Synonyms:4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol

Chemical Property of 4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol

There total 4 articles about 4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazine-5-carbaldehyde (118738-58-2) + 3-(Dimethylamino)propyl chloride (109-54-6) → 4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol (118777-78-9)

Guidance literature:

With magnesium; ethylene dibromide; In tetrahydrofuran; for 2h;

DOI:10.1016/S0040-4020(01)86057-9

Reference yield:

(8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol (118738-57-1) → 4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol (118777-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / barium manganate / CH₂Cl₂ / 6 h / Ambient temperature

2: 85 percent / 1.) Mg, ethylene dibromide / tetrahydrofuran / 2 h

With barium manganate; magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(01)86057-9

Reference yield:

pyridoxamine (85-87-0) → 4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol (118777-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 percent / dimethylformamide / 2 h / Heating

2: 68 percent / barium manganate / CH₂Cl₂ / 6 h / Ambient temperature

3: 85 percent / 1.) Mg, ethylene dibromide / tetrahydrofuran / 2 h

With barium manganate; magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)86057-9

upstream raw materials:

8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazine-5-carbaldehyde

3-(Dimethylamino)propyl chloride

(8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol

pyridoxamine

Downstream raw materials:

Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester