Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester

Base Information

Chemical Name:Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester
CAS No.:118777-79-0
Molecular Formula:C₂₂H₂₇N₃O₂S
Molecular Weight:397.541
Hs Code.:

Synonyms:Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester

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Chemical Property of Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester

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Technology Process of Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester

There total 5 articles about Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 118777-78-9
4-Dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butan-1-ol

: 507-09-5
tiolacetic acid

: 118777-79-0
Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(01)86057-9

Reference yield:

: 118738-58-2
8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazine-5-carbaldehyde

: 118777-79-0
Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 1.) Mg, ethylene dibromide / tetrahydrofuran / 2 h

2: 81 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 °C

With di-isopropyl azodicarboxylate; magnesium; ethylene dibromide; triphenylphosphine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86057-9

Reference yield:

: 118738-57-1
(8-Methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-methanol

: 118777-79-0
Thioacetic acid S-[4-dimethylamino-1-(8-methyl-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-5-yl)-butyl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / barium manganate / CH₂Cl₂ / 6 h / Ambient temperature

2: 85 percent / 1.) Mg, ethylene dibromide / tetrahydrofuran / 2 h

3: 81 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 °C

With barium manganate; di-isopropyl azodicarboxylate; magnesium; ethylene dibromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)86057-9