(R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane

Base Information

• Chemical Name: (R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane
• CAS No.: 842130-16-9
• Molecular Formula: C₁₂H₁₅F₃N₂O₄S
• Molecular Weight: 340.323
• Mol file: 842130-16-9.mol

Synonyms:(R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane

Chemical Property of (R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane

There total 1 articles about (R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(R)-2-(N-(trifluoroacetyl)amino)-1-(4'-methoxyphenyl)propane → (R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane (842130-16-9)

Guidance literature:

(R)-2-(N-(trifluoroacetyl)amino)-1-(4'-methoxyphenyl)propane; With chlorosulfonic acid; thionyl chloride; at -10 - 40 ℃; for 3h;

With ammonia; In water; acetone; at 0 - 20 ℃; for 0.166667h;

Reference yield: 89.0%

(R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane (842130-16-9) → 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide (112101-81-2)

Guidance literature:

With water; potassium carbonate; In methanol; for 8h; Heating / reflux;

Reference yield:

(R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane (842130-16-9) + 2-(o-ethoxyphenoxy)-ethyl bromide (3259-03-8) → (R)-tamsulosin (106133-20-4,106138-88-9)

Guidance literature:

(R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane; 2-(o-ethoxyphenoxy)-ethyl bromide; In methanol; for 43h; Heating / reflux;

With sodium hydroxide; In methanol; ethyl acetate;

Downstream raw materials:

tamsulosin hydrochloride

(R)-tamsulosin

5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide