bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol

Base Information

Chemical Name:bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol
CAS No.:384821-29-8
Molecular Formula:C₂₉H₃₈N₈O₂
Molecular Weight:530.673
Hs Code.:

Synonyms:bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol

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Chemical Property of bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol

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Technology Process of bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol

There total 7 articles about bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 10040-93-4
1-(2-methoxyphenyl)-imidazole

: bis(N-allyl-N-methyl-5-aminomethyl-1-methyl-1H-2-imidazolyl)ketone

: 384821-29-8
bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol

Guidance literature:: 1-(2-methoxyphenyl)-imidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -40 ℃;

bis(N-allyl-N-methyl-5-aminomethyl-1-methyl-1H-2-imidazolyl)ketone; In tetrahydrofuran; at -78 - 20 ℃; for 24h; Further stages.;
DOI:10.1021/jo010737m

Reference yield:

: 39021-62-0
1-methylimidazole-5-carbaldehyde

: 384821-29-8
bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; H₂O / 20 °C

2.1: 16.3 g / NaBH₄ / methanol; H₂O

3.1: 82 percent / Cs₂CO₃ / dimethylformamide / 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / -78 - -40 °C

4.2: 55 percent / tetrahydrofuran / 24 h / -78 - 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / -78 - -40 °C

5.2: 55 percent / tetrahydrofuran / 24 h / -78 - 20 °C

With sodium tetrahydroborate; n-butyllithium; caesium carbonate; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo010737m

Reference yield:

: 38993-84-9
(1-methyl-1H-imidazol-5-yl)methanol

: 384821-29-8
bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 71 percent / MnO₂ / CHCl₃ / 48 h / Heating

2.1: methanol; H₂O / 20 °C

3.1: 16.3 g / NaBH₄ / methanol; H₂O

4.1: 82 percent / Cs₂CO₃ / dimethylformamide / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / -78 - -40 °C

5.2: 55 percent / tetrahydrofuran / 24 h / -78 - 20 °C

6.1: n-BuLi / tetrahydrofuran; hexane / -78 - -40 °C

6.2: 55 percent / tetrahydrofuran / 24 h / -78 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; caesium carbonate; In tetrahydrofuran; methanol; hexane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo010737m